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Sedating a dog

The injectable form, however, administered oral transmucosally (OTM) offers very reliable moderate to marked sedation within 20-30 minutes.

Acepromazine elicits behavior-modifying effects primarily by drug binding and blockade of dopamine receptors in the basal ganglia and limbic system.

In the aggressive or fearful dog, this drug is best given 30-60 minutes prior to the hospital visit (send owners home with the injectable without needle, 2 doses in case one is lost during administration attempt) and instruct that effects are most profound following absorption from the oral mucosa.

Contraindications are listed, but primarily include disease states that would deter one from using acepromazine in an anesthetic protocol (Table 1).

The drug exists for veterinary use in two forms – oral and injectable – and while the oral formulation has historic use in managing at home anxieties (e.g.

thunderstorms, fireworks, etc.), it can be unreliable in terms of desired sedative effect and onset/duration are often variable.

Kate Cummings, DVM, DACVAA [email protected] Aggressive and/or fearful dogs present several challenges for the small animal practitioner.

These patients are difficult to fully evaluate and present a safety hazard to the clinic staff, veterinarian, and sometimes even the owner.

bringing overly aggressive dogs directly into an exam room vs.